| ncRNA name | Dectin-1 siRNA |
| ncRNA Category | siRNA |
| Disease name | fungal keratitis |
| Species | Mus musculus |
| Tissues/Cell_line | corneas |
| Methods | siRNA injection, RT-PCR, Western blot, immunofluorescence staining |
| Expression pattern | associated |
| Functional description | Pretreatment with Dectin-1 siRNA significantly decreased A. fumigatus-induced IL-1β production and JNK phosphorylation compared with scrambled control in C57BL/6 mice corneas.Dectin-1 induced IL-1β production is JNK dependent in mouse A. fumigatus keratitis, and suppressed apoptosis mediated anti-inflammatory response. |
| PubMed ID | 28926773 |
| Year | 2017 |
| Title | Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis. |
| Drug-related ncRNA | NO |
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